Tailoring macrocycles for metal ion binding

Tailoring macrocycles for metal ion binding

Absrract: We have been concerned with the development of alternate strategies for achievinc; metalion recognition. An important aspect of this research has been to investigate meta! ion complexation over a range of related macrocycles, incorporating different macrocyclic rhg sizes, donor atom set combinations and/or degree of ring substitution and to search for stability rrnxima at different po...

Thermodynamics of metal ion binding. 2. Metal ion binding by carbonic anhydrase variants.

The ability to construct molecular motifs with predictable properties in aqueous solution requires an extensive knowledge of the relationships between structure and energetics. The design of metal binding motifs is currently an area of intense interest in the bioorganic community. To date synthetic motifs designed to bind metal ions lack the remarkable affinities observed in biological systems....

Tyrosine modification enhances metal-ion binding.

Tyrosine sulfation is a common modification of many proteins, and the ability to phosphorylate tyrosine residues is an intrinsic property of many growth-factor receptors. In the present study, we have utilized the peptide hormone CCK(8) (cholecystokinin), which occurs naturally in both sulfated and unsulfated forms, as a model to investigate the effect of tyrosine modification on metal-ion bind...

Multifunctional Peptide Complexes for Mimicking the Metal Ion Binding Proteins

Low specificity of metal ion binding in the metal ion core of a folded RNA.

The structure and activity of nucleic acids depend on their interactions with metal ions. Fundamental to these interactions is the degree of specificity observed between the metal ions and nucleic acids, and a complete description of nucleic acid folding requires that we understand the nature of the interactions with metal ions, including specificity. The prior demonstration that high concentra...